TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans

• Main Authors: Caitlin S. Latimer (Author), Jade G. Stair (Author), Joshua C. Hincks (Author), Heather N. Currey (Author), Thomas D. Bird (Author), C. Dirk Keene (Author), Brian C. Kraemer (Author), Nicole F. Liachko (Author)
• Format: Book
• Published: The Company of Biologists, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although amyloid β (Aβ) and tau aggregates define the neuropathology of Alzheimer's disease (AD), TDP-43 has recently emerged as a co-morbid pathology in more than half of patients with AD. Individuals with concomitant Aβ, tau and TDP-43 pathology experience accelerated cognitive decline and wo...