Enhancement of in vivo hypoglycemic effect of gliclazide by developing self-microemulsifying pellet dosage form

• Main Authors: Hetal Patel (Author), Niharika Pandey (Author), Bhoomi Patel (Author), Ketan Ranch (Author), Kunjan Bodiwala (Author), Bhavin Vyas (Author)
• Format: Book
• Published: SpringerOpen, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The present research was aimed to develop a self-microemulsifying drug delivery system (SMEDDS) pellet to increase the dissolution rate and in vivo hypoglycemic effect of gliclazide. Gliclazide belongs to BCS class 2 and it exhibits dissolution rate-limited absorption. Thus, diss...