Emerging pro-drug and nano-drug strategies for gemcitabine-based cancer therapy

• Main Authors: Haijie Han (Author), Su Li (Author), Yueyang Zhong (Author), Yue Huang (Author), Kai Wang (Author), Qiao Jin (Author), Jian Ji (Author), Ke Yao (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gemcitabine has been extensively applied in treating various solid tumors. Nonetheless, the clinical performance of gemcitabine is severely restricted by its unsatisfactory pharmacokinetic parameters and easy deactivation mainly because of its rapid deamination, deficiencies in deoxycytidine kinase...