Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice

• Main Authors: Grace Fergusson (Author), Mélanie Éthier (Author), Mélanie Guévremont (Author), Chloé Chrétien (Author), Camille Attané (Author), Erik Joly (Author), Xavier Fioramonti (Author), Marc Prentki (Author), Vincent Poitout (Author), Thierry Alquier (Author)
• Format: Book
• Published: Elsevier, 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The C57Bl/6J (Bl/6J) mouse is the most widely used strain in metabolic research. This strain carries a mutation in nicotinamide nucleotide transhydrogenase (Nnt), a mitochondrial enzyme involved in NADPH production, which has been suggested to lead to glucose intolerance and beta-cell dys...