Deficits in Endogenous Adenosine Formation by Ecto-5'-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis

• Main Authors: Laura Oliveira (Author), Alexandra Correia (Author), Ana Cristina Costa (Author), Sónia Guerra-Gomes (Author), Fátima Ferreirinha (Author), Maria Teresa Magalhães-Cardoso (Author), Manuel Vilanova (Author), Paulo Correia- (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AMP dephosphorylation via ecto-5'-nucleotidase/CD73 is the rate limiting step to generate extracellular adenosine (ADO) from released adenine nucleotides. ADO, via A2A receptors (A2ARs), is a potent modulator of neuromuscular and immunological responses. The pivotal role of ecto-5'-nucleot...