Deficits in Endogenous Adenosine Formation by Ecto-5'-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis

• Prif Awduron: Laura Oliveira (Awdur), Alexandra Correia (Awdur), Ana Cristina Costa (Awdur), Sónia Guerra-Gomes (Awdur), Fátima Ferreirinha (Awdur), Maria Teresa Magalhães-Cardoso (Awdur), Manuel Vilanova (Awdur), Paulo Correia- (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Hindawi Limited, 2015-01-01T00:00:00Z.
• Pynciau: article
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AMP dephosphorylation via ecto-5'-nucleotidase/CD73 is the rate limiting step to generate extracellular adenosine (ADO) from released adenine nucleotides. ADO, via A2A receptors (A2ARs), is a potent modulator of neuromuscular and immunological responses. The pivotal role of ecto-5'-nucleot...