Development of Biodegradable Polycation-Based Inhalable Dry Gene Powders by Spray Freeze Drying

• Main Authors: Tomoyuki Okuda (Author), Yumiko Suzuki (Author), Yuko Kobayashi (Author), Takehiko Ishii (Author), Satoshi Uchida (Author), Keiji Itaka (Author), Kazunori Kataoka (Author), Hirokazu Okamoto (Author)
• Format: Book
• Published: MDPI AG, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, two types of biodegradable polycation (PAsp(DET) homopolymer and PEG-PAsp(DET) copolymer) were applied as vectors for inhalable dry gene powders prepared by spray freeze drying (SFD). The prepared dry gene powders had spherical and porous structures with a 5~10-μm diameter, and the in...