Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty

• Main Authors: Francesca Aiello (Author), Grazia Cirillo (Author), Alessandra Cassio (Author), Raffaella Di Mase (Author), Gianluca Tornese (Author), Giuseppina R. Umano (Author), Emanuele Miraglia del Giudice (Author), Anna Grandone (Author)
• Format: Book
• Published: BMC, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Prokineticin receptor 2 (PROKR2) loss of function mutations have been described as cause of hypogonadotropic hypogonadism. In 2017, a first case of central precocious puberty (CPP) caused by PROKR2 heterozygous gain of function mutation was described in a 3.5 years-old girl. No o...