A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates.

• Main Authors: Karthik Mallilankaraman (Author), Devon J Shedlock (Author), Huihui Bao (Author), Omkar U Kawalekar (Author), Paolo Fagone (Author), Aarthi A Ramanathan (Author), Bernadette Ferraro (Author), Jennifer Stabenow (Author), Paluru Vijayachari (Author), Senthil G Sundaram (Author), Nagarajan Muruganandam (Author), Gopalsamy Sarangan (Author), Padma Srikanth (Author), Amir S Khan (Author), Mark G Lewis (Author), J Joseph Kim (Author), Niranjan Y Sardesai (Author), Karuppiah Muthumani (Author), David B Weiner (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus indigenous to tropical Africa and Asia. Acute illness is characterized by fever, arthralgias, conjunctivitis, rash, and sometimes arthritis. Relatively little is known about the antigenic targets for immunity, and no licensed vaccine...