Safety of Liver Surface Instillation of Plasmid DNA in Normal and Carbon Tetrachloride-Induced Hepatitis Mice

Purpose. We previously demonstrated liver- and lobe-selective gene transfer following instillation of plasmid DNA (pDNA) onto the liver surface in mice. Safety concerns must be resolved prior to future clinical use. Thus, we investigated safety of liver surface instillation of pDNA in normal and hep...

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主要な著者: Shintaro Fumoto (著者), Hiroyuki Furukawa (著者), Junzo Nakamura (著者), Koyo Nishida (著者)
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出版事項: Frontiers Media S.A., 2011-06-01T00:00:00Z.
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