Polydatin ameliorates early brain injury after subarachnoid hemorrhage through up-regulating SIRT1 to suppress endoplasmic reticulum stress

• Main Authors: Yuwei Han (Author), Guangzhi Hao (Author), Song Han (Author), Tingzhun Zhu (Author), Yushu Dong (Author), Ligang Chen (Author), Xinyu Yang (Author), Xiaoming Li (Author), Hai Jin (Author), Guobiao Liang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ObjectiveThis study aims to investigate the inhibitory effect of Polydatin (PD) on endoplasmic reticulum (ER) stress following subarachnoid hemorrhage (SAH) and to elucidate the underlying mechanisms.MethodsA standard intravascular puncture model was established to mimic SAH in mice. Neurological fu...