Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity

The leading hypothesis on Alzheimer Disease (AD) is that it is caused by buildup of the peptide amyloid-beta (Abeta), which initially causes dysregulation of synaptic plasticity and eventually causes destruction of synapses and neurons. Pharmacological efforts to limit Abeta buildup have proven inef...

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Autor Principal: Thomas J. Anastasio (Author)
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Publicado: Frontiers Media S.A., 2014-05-01T00:00:00Z.
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