Identification of novel non-toxic and anti-angiogenic α-fluorinated chalcones as potent colchicine binding site inhibitors

• Main Authors: Moran Sun (Author), Minghua Yuan (Author), Yingying Kang (Author), Jinling Qin (Author), Yixin Zhang (Author), Yongtao Duan (Author), Longfei Wang (Author), Yongfang Yao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

α-Fluorinated chalcones were prepared and evaluated for their cell growth inhibitory properties against six human cancer cell lines. The most potent chalcone 4c demonstrated excellent selective toxicity against cancer cells versus normal human cells, with IC50 values at nanomolar concentration range...