Population Pharmacokinetics and Pharmacodynamics of Benralizumab in Healthy Volunteers and Patients With Asthma

• Main Authors: B Wang (Author), L Yan (Author), Z Yao (Author), LK Roskos (Author)
• Format: Bog
• Udgivet: Wiley, 2017-04-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Benralizumab is a humanized, afucosylated, anti‐interleukin‐5 receptor α, immunoglobulin G (IgG) 1 κ monoclonal antibody. We developed a population pharmacokinetic (PK)/pharmacodynamic (PD) model for benralizumab by analyzing PK and blood eosinophil count data from two healthy volunteer studies (N =...