Modelling the MYC-driven normal-to-tumour switch in breast cancer

• Main Authors: Corey Lourenco (Author), Manpreet Kalkat (Author), Kathleen E. Houlahan (Author), Jason De Melo (Author), Joseph Longo (Author), Susan J. Done (Author), Paul C. Boutros (Author), Linda Z. Penn (Author)
• Format: Book
• Published: The Company of Biologists, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The potent MYC oncoprotein is deregulated in many human cancers, including breast carcinoma, and is associated with aggressive disease. To understand the mechanisms and vulnerabilities of MYC-driven breast cancer, we have generated an in vivo model that mimics human disease in response to MYC deregu...