Oxaliplatin administration increases expression of the voltage-dependent calcium channel α2δ-1 subunit in the rat spinal cord

• Main Authors: Ken Yamamoto (Author), Mayuko Tsuboi (Author), Toshie Kambe (Author), Kenji Abe (Author), Yoshihiko Nakatani (Author), Kazuyoshi Kawakami (Author), Iku Utsunomiya (Author), Kyoji Taguchi (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin is a chemotherapeutic agent that is effective against various types of cancer including colorectal cancer. Acute cold hyperalgesia is a serious side effect of oxaliplatin treatment. Although the therapeutic drug pregabalin is beneficial for preventing peripheral neuropathic pain by targe...