The hypothalamic-pituitary-gonadal axis controls muscle stem cell senescence through autophagosome clearance

• Main Authors: Ji‐Hoon Kim (Author), Inkuk Park (Author), Hijai R. Shin (Author), Joonwoo Rhee (Author), Ji‐Yun Seo (Author), Young‐Woo Jo (Author), Kyusang Yoo (Author), Sang‐Hyeon Hann (Author), Jong‐Seol Kang (Author), Jieon Park (Author), Ye Lynne Kim (Author), Ju‐Yeon Moon (Author), Man Ho Choi (Author), Young‐Yun Kong (Author)
• Format: Book
• Published: Wiley, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background With organismal aging, the hypothalamic-pituitary-gonadal (HPG) activity gradually decreases, resulting in the systemic functional declines of the target tissues including skeletal muscles. Although the HPG axis plays an important role in health span, how the HPG axis systemicall...