Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma

• Main Authors: Wong Nora (Author), Ferrando Barbara (Author), Pasini Barbara (Author), Menko Fred H (Author), Oomen Peter HN (Author), Jansen Jeroen C (Author), Weiss Marjan M (Author), van Minderhout Ivonne (Author), Bayley Jean-Pierre (Author), Alpert Lesley C (Author), Williams Rosie (Author), Blair Edward (Author), Devilee Peter (Author), Taschner Peter EM (Author)
• Format: Book
• Published: BMC, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Germline mutations of the SDHD, SDHB and SDHC genes, encoding three of the four subunits of succinate dehydrogenase, are a major cause of hereditary paraganglioma and pheochromocytoma, and demonstrate that these genes are classic tum...