Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters

• Main Authors: Ryan P. Goguen (Author), Olivier Del Corpo (Author), Camille M.G. Malard (Author), Aïcha Daher (Author), Sergio P. Alpuche-Lazcano (Author), Michelle J. Chen (Author), Robert J. Scarborough (Author), Anne Gatignol (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The expression of short hairpin RNAs (shRNAs) in cells has many potential therapeutic applications, including as a functional cure for HIV. The RNA polymerase III promoters H1, 7SK, and U6 have all been used to express shRNAs. However, there have been no direct and simultaneous comparisons of shRNA...