Cooperation between CD4+ T Cells and Humoral Immunity Is Critical for Protection against Dengue Using a DNA Vaccine Based on the NS1 Antigen.

• Main Authors: Antônio J S Gonçalves (Author), Edson R A Oliveira (Author), Simone M Costa (Author), Marciano V Paes (Author), Juliana F A Silva (Author), Adriana S Azevedo (Author), Marcio Mantuano-Barradas (Author), Ana Cristina M A Nogueira (Author), Cecília J Almeida (Author), Ada M B Alves (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue virus (DENV) is spread through most tropical and subtropical areas of the world and represents a serious public health problem. At present, the control of dengue disease is mainly hampered by the absence of antivirals or a vaccine, which results in an estimated half worldwide population at ri...