Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite

Ticagrelor is the first reversibly binding, direct-acting, oral P2Y12 receptor inhibitor. The contribution of UDP-glucuronosyltransferases (UGTs) enzymes to the metabolism of ticagrelor to its glucuronide conjugation, ticagrelor-O-glucuronide, in human liver microsomes (HLM) and human intestinal mic...

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Main Authors: Shuaibing Liu (Author), Lei Hou (Author), Cai Li (Author), Yibo Zhao (Author), Xia Yao (Author), Xiaojian Zhang (Author), Xin Tian (Author)
Format: Book
Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
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