Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite

Ticagrelor is the first reversibly binding, direct-acting, oral P2Y12 receptor inhibitor. The contribution of UDP-glucuronosyltransferases (UGTs) enzymes to the metabolism of ticagrelor to its glucuronide conjugation, ticagrelor-O-glucuronide, in human liver microsomes (HLM) and human intestinal mic...

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Váldodahkkit: Shuaibing Liu (Dahkki), Lei Hou (Dahkki), Cai Li (Dahkki), Yibo Zhao (Dahkki), Xia Yao (Dahkki), Xiaojian Zhang (Dahkki), Xin Tian (Dahkki)
Materiálatiipa: Girji
Almmustuhtton: Frontiers Media S.A., 2021-10-01T00:00:00Z.
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3rd Floor Main Library

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