Retrospective and Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl peptidase-IV Inhibitors Using Simple Allometric Principles - Case Studies of ABT-279, ABT-341, Alogliptin, Carmegliptin, Sitagliptin and Vildagliptin

• मुख्य लेखकों: Ravindranath R Gilibili (लेखक), Ravi Kanth Bhamidipati (लेखक), Ramesh Mullangi (लेखक), Nuggehally R Srinivas (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2015-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Purpose: The purpose of this exercise was to explore the utility of allometric scaling approach for the prediction of intravenous and oral pharmacokinetics of six dipeptidy peptidase-IV (DPP-IV) inhibitors viz. ABT-279, ABT-341, alogliptin, carmegliptin, sitagliptin and vildagliptin. Methods: The av...