Retrospective and Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl peptidase-IV Inhibitors Using Simple Allometric Principles - Case Studies of ABT-279, ABT-341, Alogliptin, Carmegliptin, Sitagliptin and Vildagliptin

• Main Authors: Ravindranath R Gilibili (Author), Ravi Kanth Bhamidipati (Author), Ramesh Mullangi (Author), Nuggehally R Srinivas (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2015-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Purpose: The purpose of this exercise was to explore the utility of allometric scaling approach for the prediction of intravenous and oral pharmacokinetics of six dipeptidy peptidase-IV (DPP-IV) inhibitors viz. ABT-279, ABT-341, alogliptin, carmegliptin, sitagliptin and vildagliptin. Methods: The av...