Retrospective and Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl peptidase-IV Inhibitors Using Simple Allometric Principles - Case Studies of ABT-279, ABT-341, Alogliptin, Carmegliptin, Sitagliptin and Vildagliptin

Purpose: The purpose of this exercise was to explore the utility of allometric scaling approach for the prediction of intravenous and oral pharmacokinetics of six dipeptidy peptidase-IV (DPP-IV) inhibitors viz. ABT-279, ABT-341, alogliptin, carmegliptin, sitagliptin and vildagliptin. Methods: The av...

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Váldodahkkit: Ravindranath R Gilibili (Dahkki), Ravi Kanth Bhamidipati (Dahkki), Ramesh Mullangi (Dahkki), Nuggehally R Srinivas (Dahkki)
Materiálatiipa: Girji
Almmustuhtton: Frontiers Media S.A., 2015-09-01T00:00:00Z.
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