Ex vivo and in vitro Monocyte Responses Do Not Reflect in vivo Immune Responses and Tolerance

• Main Authors: Aron Jansen (Author), Niklas Bruse (Author), Nicole Waalders (Author), Jelle Gerretsen (Author), Daniëlle Rijbroek (Author), Peter Pickkers (Author), Matthijs Kox (Author)
• Format: Book
• Published: Karger Publishers, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytokine production by ex vivo (EV)-stimulated leukocytes is commonly used to gauge immune function and frequently proposed to guide immunomodulatory therapy. However, whether EV cytokine production capacity accurately reflects the in vivo (IV) immune status is largely unknown. We investigated relat...