A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα

• Main Authors: Alessandra Ammazzalorso (Author), Stefania Tacconelli (Author), Annalisa Contursi (Author), Ulrika Hofling (Author), Carmen Cerchia (Author), Sara Di Berardino (Author), Alessandra De Michele (Author), Rosa Amoroso (Author), Antonio Lavecchia (Author), Paola Patrignani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundPPARα and cyclooxygenase (COX)-2 are overexpressed in certain types of cancer. Thus, developing a dual inhibitor that targets both could be more effective as an anticancer agent than single inhibitors. We have previously shown that an analog of the bezafibrate named AA520 is a PPARα antago...