Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy

• Main Authors: Xiaodi Liu (Author), Qi Zhang (Author), Yixia Liang (Author), Shiyu Xiong (Author), Yan Cai (Author), Jincheng Cao (Author), Yanni Xu (Author), Xiaolin Xu (Author), Ye Wu (Author), Qiang Lu (Author), Xiaoding Xu (Author), Baoming Luo (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T cell infiltration and proliferation in tumor tissues are the main factors that significantly affect the therapeutic outcomes of cancer immunotherapy. Emerging evidence has shown that interferon-gamma (IFNγ) could enhance CXCL9 secretion from macrophages to recruit T cells, but Siglec15 expressed o...