A Novel Drug Resistance Mechanism: Genetic Loss of Xeroderma Pigmentosum Complementation Group C (XPC) Enhances Glycolysis-Mediated Drug Resistance in DLD-1 Colon Cancer Cells

• Main Authors: Yu Han (Author), Yuan Qing Qu (Author), Simon Wing Fai Mok (Author), Juan Chen (Author), Cheng Lai Xia (Author), Hu Qiang He (Author), Zheng Li (Author), Wei Zhang (Author), Cong Ling Qiu (Author), Liang Liu (Author), Betty Yuen Kwan Law (Author), Vincent Kam Wai Wong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pro-apoptotic proteins BAX and BAK are critical regulatory factors constituting the apoptosis machinery. Downregulated expression of BAX and BAK in human colorectal cancer lead to chemotherapeutic failure and poor survival rate in patients. In this study, isogenic DLD-1 colon cancer cells and th...