Synthesis, in vitro enzyme activity and molecular docking studies of new benzylamine-sulfonamide derivatives as selective MAO-B inhibitors

• Main Authors: Begüm Nurpelin Sağlık (Author), Derya Osmaniye (Author), Ulviye Acar Çevik (Author), Serkan Levent (Author), Betül Kaya Çavuşoğlu (Author), Özlem Atlı Eklioğlu (Author), Yusuf Özkay (Author), Ali Savaş Koparal (Author), Zafer Asım Kaplancıklı (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many studies have been conducted on the selective inhibition of human monoamine oxidase B (hMAO-B) enzyme using benzylamine-sulphonamide derivatives. Using various chemical modifications on BB-4h, which was reported previously by our team and showed a significant level of MAO-B inhibition, novel ben...