Empagliflozin mitigates methotrexate-induced nephrotoxicity in male albino rats: insights on the crosstalk of AMPK/Nrf2 signaling pathway

• Main Authors: Amal Anwar Mishriki (Author), Amira Karam Khalifa (Author), Dina Anwar Ibrahim (Author), Ghada Mohamed Abdel Zaher Hashem (Author), Laila Ahmed Rashed (Author), Sahar Samir Abdelrahman (Author), Hesham M. Mahmoud (Author)
• Format: Book
• Published: SpringerOpen, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The anti-diabetic drug, empagliflozin (EMPA), has many pleiotropic actions and is challenged recently to possess renoprotective properties. This renoprotective potential is proposed to be mediated via the activation of AMP-activated protein kinase (AMPK)/nuclear factor erythroid...