Lung cancer cell-intrinsic IL-15 promotes cell migration and sensitizes murine lung tumors to anti-PD-L1 therapy

• Main Authors: Shaojie Hu (Author), Kelin Meng (Author), Tianlai Wang (Author), Rirong Qu (Author), Boyu Wang (Author), Yu Xi (Author), Taiyan Yu (Author), Zhiwei Yuan (Author), Zihao Cai (Author), Yitao Tian (Author), Chenxi Zeng (Author), Xue Wang (Author), Wenbin Zou (Author), Xiangning Fu (Author), Lequn Li (Author)
• Format: Book
• Published: BMC, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background IL-15 plays a vital role in enhancing NK cell- and T-cell-mediated antitumor immune responses; however, the direct effect of IL-15 on tumor cells has not been fully elucidated. Herein, we investigated the effect of IL-15 on lung adenocarcinoma cells. Methods Silencing and overexp...