Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy

• Main Authors: Risa Domoto (Author), Fumiko Sekiguchi (Author), Riki Kamaguchi (Author), Maiko Iemura (Author), Hiroki Yamanishi (Author), Maho Tsubota (Author), Dengli Wang (Author), Masahiro Nishibori (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the role of ATP and high mobility group box 1 (HMGB1) in paclitaxel-induced peripheral neuropathy (PIPN). PIPN in mice was prevented by HMGB1 neutralization, macrophage depletion, and P2X7 or P2X4 blockade. Paclitaxel and ATP synergistically released HMGB1 from macrophage-like RAW264.7 c...