Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues
The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose of 100 mg/kg. The values of ALM-802 tissue availab...
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| Main Authors: | , , , , |
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| Format: | Book |
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LLC "Publisher OKI",
2022-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose of 100 mg/kg. The values of ALM-802 tissue availability were determined. Tissue availability of ALM-802 falls in a row: kidneys→liver→heart→spleen→skeletal muscle→brain (129.3; 27.2; 20.9; 15.3; 5.9 and 0.3, respectively). It was found that ALM-802 is excreted from the body rather slowly: kel values ranged from 0.0252 to 0.0885 h-1, MRT values were 7.6-59.3 h. |
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| Item Description: | 2587-7836 2686-8830 10.37489/2587-7836-2022-2-17-22 |