Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP

• Main Authors: Tongzhou Liang (Author), Jincheng Qiu (Author), Shaoguang Li (Author), Zhihuai Deng (Author), Xianjian Qiu (Author), Wenjun Hu (Author), Pengfei Li (Author), Taiqiu Chen (Author), Zhancheng Liang (Author), Hang Zhou (Author), Bo Gao (Author), Dongsheng Huang (Author), Anjing Liang (Author), Wenjie Gao (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intervertebral disc degenerative disease (IDD) is the most common degenerative spine disease, which leads to chronic low back pain and symptoms in the lower extremities. In this study, we found that RORα, a member of the retinoid-related orphan receptor family, is significantly elevated in nucleus p...