Predicting Efavirenz Concentrations in the Brain Tissue of HIV‐Infected Individuals and Exploring their Relationship to Neurocognitive Impairment

• Main Authors: Nithya Srinivas (Author), Sarah Beth Joseph (Author), Kevin Robertson (Author), Laura P. Kincer (Author), Prema Menezes (Author), Lourdes Adamson (Author), Amanda P. Schauer (Author), Kimberly H. Blake (Author), Nicole White (Author), Craig Sykes (Author), Paul Luciw (Author), Joseph J. Eron (Author), Alan Forrest (Author), Richard W. Price (Author), Serena Spudich (Author), Ronald Swanstrom (Author), Angela D.M. Kashuba (Author)
• Format: Book
• Published: Wiley, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sparse data exist on the penetration of antiretrovirals into brain tissue. In this work, we present a framework to use efavirenz (EFV) pharmacokinetic (PK) data in plasma, cerebrospinal fluid (CSF), and brain tissue of eight rhesus macaques to predict brain tissue concentrations in HIV‐infected indi...