Predicting Efavirenz Concentrations in the Brain Tissue of HIV‐Infected Individuals and Exploring their Relationship to Neurocognitive Impairment
Sparse data exist on the penetration of antiretrovirals into brain tissue. In this work, we present a framework to use efavirenz (EFV) pharmacokinetic (PK) data in plasma, cerebrospinal fluid (CSF), and brain tissue of eight rhesus macaques to predict brain tissue concentrations in HIV‐infected indi...
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Materyal Türü: | Kitap |
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Wiley,
2019-05-01T00:00:00Z.
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A1234.567 |
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Kopya Bilgisi 1 | Kütüphanede |