Discovery of Small Molecules as Membrane-Bound Catechol-<i>O</i>-methyltransferase Inhibitors with Interest in Parkinson's Disease: Pharmacophore Modeling, Molecular Docking and In Vitro Experimental Validation Studies

Discovery of Small Molecules as Membrane-Bound Catechol-<i>O</i>-methyltransferase Inhibitors with Interest in Parkinson's Disease: Pharmacophore Modeling, Molecular Docking and In Vitro Experimental Validation Studies

A pharmacophore-based virtual screening methodology was used to discover new catechol-<i>O</i>-methyltransferase (COMT) inhibitors with interest in Parkinson's disease therapy. To do so, pharmacophore models were constructed using the structure of known inhibitors and then they were...

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Main Authors: Pedro Cruz-Vicente (Author), Ana M. Gonçalves (Author), Octávio Ferreira (Author), João A. Queiroz (Author), Samuel Silvestre (Author), Luís A. Passarinha (Author), Eugenia Gallardo (Author)
Format: Book
Published: MDPI AG, 2021-12-01T00:00:00Z.
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3rd Floor Main Library

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