Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma

• Main Authors: Qiuyun Yuan (Author), Wanchun Yang (Author), Shuxin Zhang (Author), Tengfei Li (Author), Mingrong Zuo (Author), Xingwang Zhou (Author), Junhong Li (Author), Mao Li (Author), Xiaoqiang Xia (Author), Mina Chen (Author), Yanhui Liu (Author)
• Format: Book
• Published: BMC, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Malignant glioma exerts a metabolic shift from oxidative phosphorylation (OXPHOs) to aerobic glycolysis, with suppressed mitochondrial functions. This phenomenon offers a proliferation advantage to tumor cells and decrease mitochondria-dependent cell death. However, the underlyin...