Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model

• Главные авторы: Rainer Hubmann (Автор), Wolfgang Sieghart (Автор), Susanne Schnabl (Автор), Mohammad Araghi (Автор), Martin Hilgarth (Автор), Marlies Reiter (Автор), Dita Demirtas (Автор), Peter Valent (Автор), Christoph Zielinski (Автор), Ulrich Jäger (Автор), Medhat Shehata (Автор)
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• Опубликовано: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• Предметы: article
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Deregulation of NOTCH2 signaling is implicated in a wide variety of human neoplasias. The current concept of targeting NOTCH is based on using gamma secretase inhibitors (GSI) to regulate the release of the active NOTCH intracellular domain. However, the clinical outcome of GSI remains unsatisfactor...