Eplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability

• Glavni autori: Muhammad Ayub Khan (Autor), Muhammad Mohsin Ansari (Autor), Sadia Tabassam Arif (Autor), Abida Raza (Autor), Ho-Ik Choi (Autor), Chang-Wan Lim (Autor), Ha-Yeon Noh (Autor), Jin-Su Noh (Autor), Salman Akram (Autor), Hafiz Awais Nawaz (Autor), Muhammad Ammad (Autor), Abir Abdullah Alamro (Autor), Amani Ahmed Alghamdi (Autor), Jin-Ki Kim (Autor), Alam Zeb (Autor)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Poor aqueous solubility of eplerenone (EPL) is a major obstacle to achieve sufficient bioavailability after oral administration. In this study, we aimed to develop and evaluate eplerenone nanocrystals (EPL-NCs) for solubility and dissolution enhancement. D-optimal combined mixture process using Desi...