Eplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability

• Main Authors: Muhammad Ayub Khan (Author), Muhammad Mohsin Ansari (Author), Sadia Tabassam Arif (Author), Abida Raza (Author), Ho-Ik Choi (Author), Chang-Wan Lim (Author), Ha-Yeon Noh (Author), Jin-Su Noh (Author), Salman Akram (Author), Hafiz Awais Nawaz (Author), Muhammad Ammad (Author), Abir Abdullah Alamro (Author), Amani Ahmed Alghamdi (Author), Jin-Ki Kim (Author), Alam Zeb (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Poor aqueous solubility of eplerenone (EPL) is a major obstacle to achieve sufficient bioavailability after oral administration. In this study, we aimed to develop and evaluate eplerenone nanocrystals (EPL-NCs) for solubility and dissolution enhancement. D-optimal combined mixture process using Desi...