Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty

• Main Authors: Maria Manfredi-Lozano (Author), Juan Roa (Author), Francisco Ruiz-Pino (Author), Richard Piet (Author), David Garcia-Galiano (Author), Rafael Pineda (Author), Aurora Zamora (Author), Silvia Leon (Author), Miguel A. Sanchez-Garrido (Author), Antonio Romero-Ruiz (Author), Carlos Dieguez (Author), Maria Jesus Vazquez (Author), Allan E. Herbison (Author), Leonor Pinilla (Author), Manuel Tena-Sempere (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Puberty is a key developmental phenomenon highly sensitive to metabolic modulation. Worrying trends of changes in the timing of puberty have been reported in humans. These might be linked to the escalating prevalence of childhood obesity and could have deleterious impacts on later (cardio...