Identification of the Target for a Transition Metal-α-Amino Acid Complex Antibiotic Against Mycobacterium smegmatis
Spontaneous mutants of Mycobacterium smegmatis strain mc2155 resistant to 1-PG (iridium-L-phenylglycine complex), an antimycobacterial antibiotic, were isolated. Based on the discovery that some 1-PG-resistant mutants (1-PGR) were also resistant to high concentrations of clarithromycin (≥250 μg/ml),...
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Main Authors: | George W. Karpin (Author), Joseph S. Merola (Author), Joseph O. Falkinham (Author) |
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Format: | Book |
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Frontiers Media S.A.,
2021-06-01T00:00:00Z.
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