Orthogonal quantification of soluble inducible T-cell costimulator (ICOS) in healthy and diseased human serum

• Auteurs principaux: Kevin McKinski (Auteur), Dean McNulty (Auteur), Francesca Zappacosta (Auteur), Mary Birchler (Auteur), Matt Szapacs (Auteur), Christopher Evans (Auteur)
• Format: Livre
• Publié: Elsevier, 2022-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Inducible T-cell costimulator (ICOS), a homodimeric protein expressed on the surface of activated T-cells, is being investigated as a potential therapeutic target to treat various cancers. Recent studies have reported aberrant increases in the soluble form of ICOS (sICOS) in human serum in disease-s...