Orthogonal quantification of soluble inducible T-cell costimulator (ICOS) in healthy and diseased human serum

• Main Authors: Kevin McKinski (Author), Dean McNulty (Author), Francesca Zappacosta (Author), Mary Birchler (Author), Matt Szapacs (Author), Christopher Evans (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inducible T-cell costimulator (ICOS), a homodimeric protein expressed on the surface of activated T-cells, is being investigated as a potential therapeutic target to treat various cancers. Recent studies have reported aberrant increases in the soluble form of ICOS (sICOS) in human serum in disease-s...