Orthogonal quantification of soluble inducible T-cell costimulator (ICOS) in healthy and diseased human serum

• Egile Nagusiak: Kevin McKinski (Egilea), Dean McNulty (Egilea), Francesca Zappacosta (Egilea), Mary Birchler (Egilea), Matt Szapacs (Egilea), Christopher Evans (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2022-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Inducible T-cell costimulator (ICOS), a homodimeric protein expressed on the surface of activated T-cells, is being investigated as a potential therapeutic target to treat various cancers. Recent studies have reported aberrant increases in the soluble form of ICOS (sICOS) in human serum in disease-s...