Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M3 Muscarinic Acetylcholine Receptor

• Main Authors: Lihui Zhao (Author), Tingting Chen (Author), Pengzhou Hang (Author), Wen Li (Author), Jing Guo (Author), Yang Pan (Author), Jingjing Du (Author), Yuyang Zheng (Author), Zhimin Du (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Choline has been reported to produce a variety of cellular functions including cardioprotection via activating M3 muscarinic acetylcholine receptor (M3R) under various insults. However, whether choline offers similar beneficial effects via the same mechanism in cardiac fibrosis remained unexplored....