An Oligodeoxynucleotide with AAAG Repeats Significantly Attenuates Burn-induced Systemic inflammatory Responses by inhibiting interferon Regulatory Factor 5 Pathway

• Main Authors: Yue Xiao (Author), Wenting Lu (Author), Xin Li (Author), Peiyan Zhao (Author), Yun Yao (Author), Xiaohong Wang (Author), Ying Wang (Author), Zhipeng Lin (Author), Yongli Yu (Author), Shucheng Hua (Author), Liying Wang (Author)
• Format: Book
• Published: BMC, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Previously, we showed that an oligodeoxynucleotide (ODN) with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis factor-α (TNF-α) in the injured lungs. However, its underlying mechanisms remain to be...