Ameliorating the antitumor activity of lenalidomide using PLGA nanoparticles for the treatment of multiple myeloma

• Main Authors: Veera Venkata Satyanarayana Reddy Karri (Author), Nagasamy Venkatesh Dhandapani (Author), Sai Sandeep Mannemala (Author), Kollipara Radhakrishna (Author), Shashank Mulukutla (Author), Dedeepya Sudunagunta (Author)
• Format: Book
• Published: Universidade de São Paulo, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Lenalidomide (LND) is an anti-cancer drug and an effective derivative of thalidomide used for multiple myeloma therapy. Because of its poor solubility in water, LND is known to cause low oral bioavailability (below 33%), and as a direct consequence of this, the dosing frequency is extended...