Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and Exploring Downstream Processability

• Main Authors: Edit Hirsch (Author), Márió Nacsa (Author), Eszter Pantea (Author), Edina Szabó (Author), Panna Vass (Author), Júlia Domján (Author), Attila Farkas (Author), Zoltán Nyíri (Author), Zsuzsanna Eke (Author), Tamás Vigh (Author), Sune Klint Andersen (Author), Geert Verreck (Author), György János Marosi (Author), Zsombor Kristóf Nagy (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as a stabilizer and as an electrospinning matrix. In order to optimize the morphology of the fibers, electrospinning of various formul...