Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity

• Main Authors: David P. Sparling (Author), Junjie Yu (Author), KyeongJin Kim (Author), Changyu Zhu (Author), Sebastian Brachs (Author), Andreas L. Birkenfeld (Author), Utpal B. Pajvani (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: As the obesity pandemic continues to expand, novel molecular targets to reduce obesity-related insulin resistance and Type 2 Diabetes (T2D) continue to be needed. We have recently shown that obesity is associated with reactivated liver Notch signaling, which, in turn, increases hepatic in...