CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways

• Главные авторы: Jing Li (Автор), Jiamin Liang (Автор), Liwei Wu (Автор), Yang Xu (Автор), Chengxiang Xiao (Автор), Xue Yang (Автор), Ran Sun (Автор), Jinmin Zhao (Автор), Jiake Xu (Автор), Qian Liu (Автор), Bo Zhou (Автор)
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• Опубликовано: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Предметы: article
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Osteoclasts are of hematopoietic lineage and have the ability to degrade mineralized bone tissues. Abnormalities in osteoclastic activity under certain pathological conditions are common in bone diseases such as osteoporosis, osteosclerosis, and arthritis. Although many kinds of drugs are currently...