CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways

• Main Authors: Jing Li (Author), Jiamin Liang (Author), Liwei Wu (Author), Yang Xu (Author), Chengxiang Xiao (Author), Xue Yang (Author), Ran Sun (Author), Jinmin Zhao (Author), Jiake Xu (Author), Qian Liu (Author), Bo Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoclasts are of hematopoietic lineage and have the ability to degrade mineralized bone tissues. Abnormalities in osteoclastic activity under certain pathological conditions are common in bone diseases such as osteoporosis, osteosclerosis, and arthritis. Although many kinds of drugs are currently...