PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease

• Main Authors: Fabiana Morroni (Author), Giulia Sita (Author), Agnese Graziosi (Author), Gloria Ravegnini (Author), Raffaella Molteni (Author), Maria Serena Paladini (Author), Kris Simone Tranches Dias (Author), Ariele Faria dos Santos (Author), Claudio Viegas (Author), Ihosvany Camps (Author), Letizia Pruccoli (Author), Andrea Tarozzi (Author), Patrizia Hrelia (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is the most frequent type of dementia in older people. The complex nature of AD calls for the development of multitarget agents addressing key pathogenic processes. Donepezil, an acetylcholinesterase inhibitor, is a first-line acetylcholinesterase inhibitor used for the...