Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen

• Үндсэн зохиолчид: Bo Wang (Зохиогч), Chunning Yang (Зохиогч), Xiaofang Jin (Зохиогч), Qun Du (Зохиогч), Herren Wu (Зохиогч), William Dall'Acqua (Зохиогч), Yariv Mazor (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Complement-dependent cytotoxicity (CDC) is a potent effector mechanism, engaging both innate and adaptive immunity. Although strategies to improve the CDC activity of antibody therapeutics have primarily focused on enhancing the interaction between the antibody crystallizable fragment (Fc) and the f...