Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts

• Main Authors: Rachel M. Jones (Author), Phillip E. Melton (Author), Mark Pinese (Author), Alexander J. Rea (Author), Evan Ingley (Author), Mandy L. Ballinger (Author), International Sarcoma Kindred Study (Author), David J. Wood (Author), David M. Thomas (Author), Eric K. Moses (Author)
• Format: Book
• Published: BMC, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Although familial clustering of cancers is relatively common, only a small proportion of familial cancer risk can be explained by known cancer predisposition genes. Methods In this study we employed a two-stage approach to identify candidate sarcoma risk genes. First, we conducte...