Tigecycline and Gentamicin-Combined Treatment Enhances Renal Damage: Oxidative Stress, Inflammatory Reaction, and Apoptosis Interplay

• Main Authors: Dina Elgazzar (Author), Mohamed Aboubakr (Author), Heba Bayoumi (Author), Amany N. Ibrahim (Author), Safwa M. Sorour (Author), Mohamed El-Hewaity (Author), Abulmaaty M. Elsayed (Author), Shaimaa A. Shehata (Author), Khaled A. Bayoumi (Author), Mohammed Alsieni (Author), Maged Behery (Author), Doaa Abdelrahaman (Author), Samah F. Ibrahim (Author), Ahmed Abdeen (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although the combination of antibiotics is generally well-tolerated, they may have nephrotoxic effects. This study investigated whether tigecycline (TG) and gentamicin (GM) co-administration could accelerate renal damage. Male Wistar rats were randomly divided into six experimental groups: the contr...